On our recent trip, I rented a vehicle to drive the family from Johannesburg to our safari in Greater Kruger. Most folks will realize they will be driving on the left side of the road. That is not so bad, but roundabouts can be tricky. But, what you may not realize, unless you specify, is that you may get a manual shift vehicle. You say, "No problem, I can drive a stick shift." Keep in mind you will be using the same shift pattern you are used to in the U.S. but you will be shifting with your left hand. This is the tricky bit. Also, if you drive to Kruger from J'burg, the stretch of road north of Dullstroom has the worst potholes I have ever seen. There are signs for them but also saw several vehicles with popped tires. Plus, you are likely to encounter at least a few cattle on the road at various points so be careful.